Canurta Advances Polyphenol Purification and Expands Drug Discovery Team with NRC IRAP Support

Canurta Special Science Updates

Our research and development team has been working on our Pure Polyphenol Extract Separation and Purification.

As you may know, our Polyphenol Extract is enriched in novel hemp polyphenols, including prenylated flavonoids. To purify this extract further and remove all cannabinoids, We have recently invested in a flash chromatography system. This purification technique is intended for rapid separation using air pressure, a combination of solvent and silica gel particles.

Flash Chromatography System

The team developed a unique method to separate our novel compounds of interest. The pure polyphenol extract is mixed with silica gel and compacted into a solid column. The dry hemp mixture is then loaded into the flash chromatography, separated on a silica column and collected. This method successfully targets and separates specific compounds of interest.

Preparation of Dry Extract

Flash Chromatogram

Presently, we are also using Immobilized-enzyme reactors (IMERs) to produce pure polyphenol molecules with therapeutic potential. Immobilized-enzyme reactors (IMERs) are flow-through devices containing enzymes that are physically fixed in place on a solid matrix and can still perform their catalytic activities. Immobilized-enzyme reactors (IMERs) can be used repeatedly and continuously and have been applied for biopolymer degradation, proteomics, biomarker discovery, inhibitor screening, and detection.

For the immobilized enzyme reactor, the research and development team has:

Selected a finalist for the immobilization matrix- magnetic particles.

Successfully attached four different enzymes to the matrix.

Begun testing the storage life and stability of the immobilized enzymes.

We are getting ready to test our polyphenol molecules in various tests to further validate their anti-inflammatory, longevity and health span activity, neuroprotective activity and anti-viral activity for respiratory illness.

Canurta Receives Funding from the National Research Council of Canada Industrial Research Assistance Program (NRC IRAP)

We are thrilled to share that we received NRC IRAP funding, allowing us to hire three outstanding bioinformatics scientists: Gaukhar Zhurykbay, Gurkamal Deol, and Helia Ghazinejad. They provide scientific expertise in developing Canurta’s computer-aided drug design (CADD) pipeline, particularly suited for hit expansion and lead optimization phases of drug discovery. Furthermore, the bioinformatics scientists will add tremendous value to the company.