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Biosynthesis of Cannflavins A and B from Cannabis Sativa L.

This paper discusses the biosynthesis of two specialized metabolites, cannflavin A and B, from Cannabis sativa L. which exhibit potent anti-inflammatory activity. It identifies an aromatic prenyltransferase (CsPT3) that catalyzes the regiospecific addition of either geranyl diphosphate (GPP) or dimethylallyl diphosphate (DMAPP) to the methylated flavone chrysoeriol, producing cannflavins A and B, respectively. Additionally, an O-methyltransferase (CsOMT21) was identified that converts the plant flavone luteolin to chrysoeriol. These findings offer a promising avenue for metabolic engineering strategies aimed at producing these medicinally relevant compounds.

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