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The Protective Role of Cannflavins A and B Against Cell Death in Human Skin Cells



Recent scientific investigations have uncovered the significant cytoprotective effects of cannflavins A and B, two flavonoids derived from the Cannabis sativa plant, on human keratinocytes, the predominant cell type in the outer layer of the skin. This study specifically addresses the compounds’ efficacy in combating ferroptosis—an iron-dependent form of cell death—and their counteractive measures against the cytotoxicity induced by reactive carbonyl species (RCSs), which are known markers of cellular aging and contributors to the formation of advanced glycation end products. 


Ferroptosis represents a critical pathway of cell death distinct from apoptosis or necrosis, characterized by its reliance on iron and the accumulation of lipid peroxides. The research employed a cellular model using HaCaT cells, a type of human keratinocyte, to assess the impact of RCSs and erastin, a ferroptosis inducer. Findings demonstrated that cannflavins A and B notably improved cell viability and reduced lipid peroxidation levels, indicating a significant reduction in cell damage and death. 


Furthermore, the study elucidated the mechanism behind the protective effects of cannflavins A and B, attributing their activity to potent antioxidant properties, including the scavenging of free radicals and the inhibition of glycation processes. This dual-action approach highlights the potential of these compounds to serve as integral components in dietary strategies aimed at preventing or mitigating aging-related skin conditions. 

 

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